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Updated: May 12, 2026

High-throughput Screening for Broad-spectrum Chemical Inhibitors of RNA Viruses
Published on: May 5, 2014
Structural basis of measles virus polymerase inhibition by nonnucleoside inhibitor ERDRP-0519
Dong Wang1, Fan Bu1,2, Ge Yang1
1Section of Transcription & Gene Regulation, The Hormel Institute, University of Minnesota, Austin, MN, USA.
Abstract:
ERDRP-0519 is a potent nonnucleoside inhibitor active against measles virus (MeV) and other Morbilliviruses. Here we report cryo-EM structures of the compound bound to MeV polymerase complexes at 2.73 Å and 2.48 Å resolution, revealing a unique binding pocket in the RdRp palm subdomain that overlaps the catalytic GDN motif. These findings clarify the basis of resistance mutations, including W671, and provide a foundation for designing next-generation Paramyxovirus antivirals.
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