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Updated: Jan 15, 2026

Analyzing the Size, Shape, and Directionality of Networks of Coupled Astrocytes

Analyzing the Size, Shape, and Directionality of Networks of Coupled Astrocytes

Published on: October 4, 2018

Astrocytes modulate neuronal development by S100A6 signaling.

Valentina Cinquina¹, Evgenii O Tretiakov¹, Predrag Kalaba²

¹Department of Molecular Neurosciences, Center for Brain Research, Medical University of Vienna, Vienna, Austria.

Nature Communications

|October 13, 2025

Summary

This summary is machine-generated.

Cortical astrocytes release S100A6, a protein that inhibits neuronal connectivity by binding to CaCyBp. Maternal nutrition, like eicosapentaenoic acid intake, influences this S100A6-CaCyBp signaling during development.

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Published on: October 14, 2012

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Last Updated: Jan 15, 2026

Analyzing the Size, Shape, and Directionality of Networks of Coupled Astrocytes

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Published on: October 4, 2018

Synaptic Microcircuit Modeling with 3D Cocultures of Astrocytes and Neurons from Human Pluripotent Stem Cells

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Imaging Analysis of Neuron to Glia Interaction in Microfluidic Culture Platform MCP-based Neuronal Axon and Glia Co-culture System

Imaging Analysis of Neuron to Glia Interaction in Microfluidic Culture Platform MCP-based Neuronal Axon and Glia Co-culture System

Published on: October 14, 2012

Area of Science:

Neuroscience
Cell Biology
Developmental Biology

Background:

Neuronal morphogenesis is guided by intercellular signals from astrocytes.
Astrocytes provide factors promoting neuronal maturation.
Mechanisms by which astrocytes limit and stabilize neuronal connectivity are less understood.

Purpose of the Study:

To investigate the role of astrocyte-derived factors in limiting and stabilizing neuronal connectivity.
To identify novel signaling pathways involved in astroglia-neuron interactions during development.

Main Methods:

Identified S100A6 expression in cortical astrocytes and its binding partner CaCyBp in cortical neurons.
Investigated the functional impact of S100A6 on CaCyBp-mediated signaling and proteostasis in neurons.
Examined the influence of maternal nutritional status, specifically eicosapentaenoic acid intake, on S100A6-CaCyBp signaling in the developing brain.

Main Results:

Cortical astrocytes express and release S100A6, a calcium-binding protein.
Cortical neurons express calcyclin-binding protein (CaCyBp), which maintains the unfolded protein response and proteostasis.
Released S100A6 inhibits CaCyBp signaling, slowing protein turnover and neuritogenesis.
S100A6-CaCyBp signaling in male mice is sensitive to maternal eicosapentaenoic acid intake during gestation.

Conclusions:

S100A6 acts as an astroglia-derived morphogen regulating neuronal connectivity.
The S100A6-CaCyBp pathway modulates neuritogenesis and proteostasis.
Environmental factors, such as maternal nutrition, significantly influence this developmental signaling pathway.