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Genetically Predicted Gastroesophageal Reflux Disease and Common Thyroid Disorders: A Two-sample Mendelian
Hanxin Lv1, Xinyu Yang1,2, Ruting Zhang1
1Department of Endocrinology and Metabolism, The First Affiliated Hospital of Soochow University & School of Basic Medical Sciences, Suzhou Medical College of Soochow University, Suzhou, P.R. China.
Current Medicinal Chemistry
|October 14, 2025
Summary
Gastroesophageal Reflux Disease (GERD) increases hyperthyroidism risk and affects Thyroid Stimulating Hormone (TSH) levels. Thyroid disorders do not appear to impact GERD susceptibility, suggesting GERD management may reduce hyperthyroidism risk.
Area of Science:
- Endocrinology
- Gastroenterology
- Genetic Epidemiology
Background:
- The relationship between thyroid disorders and Gastroesophageal Reflux Disease (GERD) requires further investigation.
- This study utilizes a two-sample Mendelian Randomization (MR) approach to explore potential causal links.
Purpose of the Study:
- To determine the causal association between GERD and various thyroid diseases and functions.
- To investigate the potential impact of thyroid disorders on GERD susceptibility.
Main Methods:
- Summary statistics for GERD were obtained from the Integrative Epidemiology Unit OpenGWAS database.
- Thyroid data were sourced from the ThyroidOmics Consortium and FinnGen Project.
- Inverse Variance Weighted (IVW) algorithm and sensitivity analyses were employed, with significance set at p < 0.0021.
Main Results:
- GERD showed a causal association with increased hyperthyroidism risk (OR = 1.517, p = 2.04E-03).
- No significant causal link was found between thyroid disorders and GERD susceptibility.
- GERD was negatively associated with Thyroid Stimulating Hormone (TSH) levels (β = -0.048, p = 1.17E-03).
Conclusions:
- Genetic predisposition to GERD is linked to a higher risk of hyperthyroidism and altered TSH homeostasis.
- Effective management of GERD may be beneficial in reducing the risk of developing hyperthyroidism.
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