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Decoding the Solution for Man-at-the-End Attacks and Reverse Engineering on IoMT Devices: An Experimental Review of
Agila Harshini T1, Harini Sriraman1
1Department of Computer Science and Engineering, Vellore Institute of Technology, Chennai, Tamil Nadu, India.
Journal of Multidisciplinary Healthcare
|October 14, 2025
Summary
Man-At-The-End (MATE) attacks threaten Internet of Medical Things (IoMT) security by exploiting physical access. This research explores PUF/FPGA solutions to enhance IoMT device resilience against these critical cyber threats.
Area of Science:
- Cybersecurity
- Medical Device Security
- Internet of Medical Things (IoMT)
Background:
- The Internet of Medical Things (IoMT) is transforming healthcare with remote monitoring and treatment capabilities.
- Physical access to IoMT devices enables Man-At-The-End (MATE) attacks, compromising sensitive data and patient safety.
- Current software solutions offer insufficient protection against physical access threats.
Purpose of the Study:
- To analyze the vulnerability of IoMT devices to MATE attacks.
- To evaluate the effectiveness of Physically Unclonable Functions (PUF) and Field Programmable Gate Arrays (FPGA) in mitigating these threats.
- To propose futuristic security enhancements for IoMT devices.
Main Methods:
- Classification of critical MATE attacks specific to IoMT devices.
- Experimental validation using Arduino Uno, Raspberry Pi, and ESP32 for reverse engineering.
- Review of existing security measures and comparison with PUF/FPGA-based solutions.
Main Results:
- MATE attacks pose a significant risk to IoMT devices, leading to misdiagnosis and patient harm.
- PUF and FPGA-based security offer robust authentication, real-time processing, and obfuscation against MATE attacks.
- Analysis reveals vulnerabilities in PUF-enabled IoMT devices against specific MATE attack vectors.
Conclusions:
- PUF/FPGA-based security presents a promising approach to enhance IoMT device resilience against MATE attacks.
- Further research into tamper-proof hardware, evolvable PUF, and AI-assisted anomaly detection is crucial for future IoMT security.
- This study provides practical insights into securing IoMT devices against sophisticated cyber threats.
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