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Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Cancer Vaccines01:30

Cancer Vaccines

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Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
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Targeted Cancer Therapies02:57

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Combination Therapies and Personalized Medicine02:50

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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
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Related Experiment Video

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Uptake of New Lipid-coated Nanoparticles Containing Falcarindiol by Human Mesenchymal Stem Cells
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Advancing Cancer Immunotherapy Using Lipid Nanoparticle-Based Approaches.

Pedro Henrique Dias Moura Prazeres1, Gabriel Henrique Costa da Silva1, Gabriel Vieira Azevedo1

  • 1Department of Physiology and Biophysics, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, MG, 31270-901, Brazil.

International Journal of Nanomedicine
|October 14, 2025
PubMed
Summary

Ionizable lipid nanoparticles (LNPs) are advancing cancer immunotherapy by improving the delivery of nucleic acids for engineered T cells, cancer vaccines, and other therapies. This technology offers a scalable and accessible approach to more effective cancer treatments.

Keywords:
CAR-T cellsadoptive cell therapycancer immunotherapycancer vaccinesgene deliverylipid nanoparticles

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Area of Science:

  • Biotechnology
  • Immunology
  • Oncology

Background:

  • Cancer immunotherapy has revolutionized tumor treatment but faces challenges in application, particularly for solid tumors.
  • Limitations include production, toxicity, and inefficient delivery of engineered T cells (CAR-T cells).

Purpose of the Study:

  • To review the role of ionizable lipid nanoparticles (LNPs) in advancing nucleic acid delivery for cancer immunotherapy.
  • To explore LNP potential in improving CAR-T cell production, cancer vaccines, and other immunotherapeutic strategies.

Main Methods:

  • Review of recent advances in nucleic acid delivery technologies, focusing on LNPs.
  • Discussion of LNP applications for messenger RNA (mRNA) and DNA delivery.
  • Exploration of LNP potential for CAR-T cells, cancer vaccines, bispecific antibodies, and cytokine-based therapies.

Main Results:

  • LNPs show promise in delivering mRNA and DNA for various cancer immunotherapies.
  • Clinical success of LNP platforms in mRNA vaccines and RNA interference therapies validates their gene delivery effectiveness.
  • LNPs can be optimized for off-the-shelf formulations, enabling personalized treatments.

Conclusions:

  • LNPs are versatile carriers for therapeutic nucleic acids, addressing key challenges in cancer immunotherapy.
  • LNP technology offers potential for more effective, scalable, and accessible immunotherapeutic strategies.
  • Further development of LNP platforms can significantly advance cancer treatment options.