Bowel Urgency in Ulcerative Colitis is Independently Associated with Histologic Inflammation and Stool Form Despite...

Area of Science:

• Gastroenterology
• Inflammatory Bowel Disease Research
• Clinical Outcomes

Background:

• Bowel urgency (BU) is a significant symptom for ulcerative colitis (UC) patients.
• The relationship between BU, disease activity, and patient outcomes requires further investigation.

Purpose of the Study:

• To comprehensively evaluate the associations between bowel urgency and disease activity markers in UC patients.
• To identify independent predictors of active bowel urgency in ulcerative colitis.

Main Methods:

• 100 UC patients were enrolled and stratified by bowel urgency severity (active vs. remission).
• Evaluated clinical parameters included partial Mayo score, Mayo endoscopic subscore (MES), Nancy Index (NI), Bristol Stool Form Scale (BSFS), and IBD Disk score.
• Logistic regression analysis identified independent predictors of active BU.

Main Results:

• Active BU patients showed significantly higher histological inflammation (NI) and looser stools (BSFS).
• Histological inflammation (NI) and stool consistency (BSFS) were independently associated with active BU.
• Higher NI (OR: 1.874) and BSFS score (OR: 1.499) predicted active bowel urgency.

Conclusions:

• Histological inflammation and loose stools are key predictors of bowel urgency in UC.
• Bowel urgency can persist despite endoscopic or histological remission, necessitating targeted assessment.
• Current markers may not fully capture the burden of bowel urgency in UC patients.