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Updated: Jan 15, 2026
09:27
The Dimethylnitrosamine Induced Liver Fibrosis Model in the Rat
Published on: June 17, 2016
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Vincamine Mitigates Methotrexate-Induced Liver Fibrosis Model
Yonca Yılmaz Ürün1, Gürkan Güner2, Ejder Saylav Bora3
1Department of Gastroenterology, Yüzüncü Yıl University Medical School, Van, Türkiye.
Summary
Vincamine effectively protected rats against methotrexate-induced liver damage by reducing inflammation and fibrosis. This study highlights vincamine
Area of Science:
- Hepatology
- Toxicology
- Pharmacology
Background:
- Liver fibrosis is a significant cause of mortality and morbidity.
- Methotrexate (MTX) is a chemotherapy agent known to induce liver toxicity.
- Exploring novel therapeutic agents for liver protection is crucial.
Purpose of the Study:
- To investigate the hepatoprotective effects of vincamine against methotrexate-induced liver injury in a rat model.
- To evaluate the biochemical and histopathological changes in the liver following vincamine treatment.
Main Methods:
- Thirty male Wistar albino rats were used, with liver damage induced by methotrexate (20 mg/kg).
- Rats were treated with either saline or vincamine (50 mg/kg/day) orally for 10 days.
- Plasma and liver biomarkers including galectin-3, cytokeratin 18, MDA, ALT, and TGF-β were assessed. Histopathological examination of liver tissues was performed.
Main Results:
- Vincamine treatment significantly reduced plasma levels of galectin-3, cytokeratin 18, MDA, and ALT compared to the MTX-saline group.
- Vincamine administration led to decreased liver MDA and TGF-β levels.
- Histopathological analysis confirmed the protective effects of vincamine against liver damage.
Conclusions:
- Vincamine demonstrates significant hepatoprotective properties against methotrexate-induced liver toxicity.
- The protective mechanisms involve antioxidant, anti-inflammatory, and anti-fibrotic activities.
- Vincamine improves liver function, as evidenced by biochemical and histopathological improvements.
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