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Updated: Jan 15, 2026

Self-Assembly of Hybrid Lipid Membranes Doped with Hydrophobic Organic Molecules at the Water/Air Interface
Published on: May 1, 2020
Cavity formation energy drives the accumulation of amphiphiles at the air-water interface
Bun Chan1, Nur Afiqah Ahmad2, Junming Ho2
1Graduate School of Engineering, Nagasaki University, Nagasaki 852-8521, Japan. bun.chan@nagasaki-u.ac.jp.
Abstract:
Amphiphilicity is a key property that governs self-assembly, drug delivery and membrane permeability. We introduce a highly efficient approach based on polarisable continuum models to quantify this important property. Our modelling suggests that the accumulation of amphiphiles at the air-water interface is driven by the release of cavity formation energy in water.
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