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Updated: Jan 15, 2026
Co-immunoprecipitation Assay Using Endogenous Nuclear Proteins from Cells Cultured Under Hypoxic Conditions
Published on: August 2, 2018
Hypoxia and the cytoskeleton
Darragh Flood1, Cormac T Taylor1
1Conway Institute of Biomolecular and Biomedical Research and School of Medicine, University College Dublin, Belfield, Dublin, Ireland.
Abstract:
A highly-regulated and dynamic cytoskeleton is vital for functional cellular physiology and the maintenance of homeostasis. Although much is known about the mechanisms by which the cytoskeleton is regulated under physiological conditions, the effect of pathological stimuli and how this contributes to disease progression remains poorly understood. Hypoxia is a prominent microenvironmental feature of a range of pathological states including inflammation, cancer and ischaemia. In this review, we summarise what is known about the effects of hypoxia on the cytoskeleton and discuss the implications of this for physiology and disease.
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