Clinical Validation of Predictive Procedural Planning Software in a Real-World TAVI Population

Area of Science:

• Cardiology
• Medical Imaging
• Surgical Planning

Background:

• Preprocedural virtual planning with FEops HEARTguide™ aims to reduce transcatheter aortic valve implantation (TAVI) complications.
• Accurate aortic root measurements are crucial for successful TAVI prosthesis selection.

Purpose of the Study:

• Compare aortic root measurements between FEops HEARTguide™ and GE software.
• Validate FEops HEARTguide™'s accuracy in predicting post-TAVI paravalvular aortic regurgitation (AR) and new conduction abnormalities.

Main Methods:

• 106 TAVI patients underwent aortic root measurements using both GE software and FEops HEARTguide™.
• FEops HEARTguide™ predictions were correlated with post-TAVI AR (echocardiography, angiography, hemodynamics) and conduction abnormalities (ECG).

Main Results:

• FEops HEARTguide™ showed smaller aortic annulus dimensions and coronary ostia heights versus GE software, altering prosthesis sizing in 23% of cases.
• Predicted AR was higher in moderate AR groups but showed overlap between adjacent grades.
• Higher contact pressure index predicted new conduction abnormalities, also with patient-level overlap.

Conclusions:

• FEops HEARTguide™ tends to underestimate aortic root dimensions compared to GE software, influencing prosthesis sizing.
• The software demonstrates population-level predictive value for AR and conduction abnormalities, but individual patient predictions show overlap.