Association between the female survivors of childhood, adolescent, and young adult cancer and the adverse obstetric and feto-maternal outcomes: A systematic review and meta-analysis
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View abstract on PubMed
Summary
This summary is machine-generated.Female cancer survivors face higher risks of adverse pregnancy outcomes, including preterm birth and gestational diabetes. This study highlights increased risks for congenital anomalies and cesarean delivery in this population.
Area Of Science
- Reproductive Health
- Oncology
- Perinatology
Background
- Cancer and its treatments pose risks to future pregnancies for young female survivors.
- Assessing maternal and fetal outcomes is crucial for reproductive counseling.
Purpose Of The Study
- To determine the association between female cancer survivorship and adverse obstetric and feto-maternal outcomes.
- To evaluate risks for future pregnancies in childhood, adolescent, and young adult cancer survivors.
Main Methods
- Systematic literature search across major databases (PubMed, EMBASE, Scopus, Web of Science).
- Inclusion of studies reporting comparative feto-maternal outcomes up to December 2024.
- Meta-analysis using random effects model and assessment of evidence certainty by GRADE profile.
Main Results
- Meta-analysis of 37 studies revealed significantly higher risks for cancer survivors.
- Increased pooled relative risk (RR) for preterm birth (1.30), gestational diabetes mellitus (1.32), and congenital anomalies (1.13).
- Certainty of evidence for all outcomes was rated as very low.
Conclusions
- Female cancer survivors exhibit an elevated risk profile for adverse pregnancy outcomes.
- Key risks include preterm birth, gestational diabetes mellitus, congenital anomalies, and cesarean delivery.
- Further research is needed to clarify these associations due to very low certainty of evidence.
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