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Expression of serum microRNA 30e-5p in type 2 diabetic patients with diabetic kidney disease

Raghda E Ibrahim1, Shymaa O A Khalil1, Khadiga Abougabal1

  • 1Department of Clinical and Chemical Pathology, Faculty of Medicine, Beni-Suef University, , Beni-Suef, Egypt.

The Egyptian Journal of Immunology
|October 14, 2025
PubMed

Insights

Reduced microRNA 30e-5p expression is linked to diabetic kidney disease (DKD) in Egyptian type 2 diabetes (T2DM) patients. This finding suggests miRNA 30e-5p may serve as a prognostic biomarker for DKD development.

Area of Science:

  • Endocrinology
  • Molecular Biology
  • Nephrology

Background:

  • Type 2 diabetes (T2DM) is a leading cause of chronic kidney disease (CKD), with diabetic kidney disease (DKD) being a major complication.
  • Microalbuminuria is an early indicator of DKD.
  • MicroRNA (miRNA) 30e-5p dysregulation is implicated in T2DM progression and may act as a biomarker.

Purpose of the Study:

  • To investigate the clinical significance of miRNA 30e-5p dysregulation in T2DM patients.
  • To assess serum miRNA 30e-5p expression levels in T2DM patients with and without DKD.

Main Methods:

  • Real-time polymerase chain reaction was used to quantify serum miRNA 30e-5p levels.
  • The study included 50 participants: 25 T2DM patients with DKD and 25 T2DM patients without DKD.

Main Results:

  • Serum miRNA 30e-5p levels were significantly lower in T2DM patients with DKD compared to those without DKD (0.25 ± 0.26 vs. 0.89 ± 0.13, p < 0.001).

Conclusions:

  • miRNA 30e-5p dysregulation is associated with DKD development in Egyptian T2DM patients.
  • miRNA 30e-5p shows potential as a prognostic biomarker for DKD.

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