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Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

Modified-Release Drug Delivery Systems: Stimuli-Activated

Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...

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Multistimuli-Responsive Conductive Hydrogels for Information Encryption, Decryption, and Wearable Sensors.

Yuyu Xue1, Xiaojuan Lai1,2, Fei Hong3

  • 1Shaanxi Key Laboratory of Chemical Additives for Light Industry, Shaanxi University of Science & Technology, Xi'an, Shaanxi 710021, P. R. China.

ACS Applied Materials & Interfaces
|October 14, 2025
PubMed
Summary
This summary is machine-generated.

Researchers developed a novel conductive hydrogel responsive to temperature, ethanol, and salt. This stimuli-responsive material offers potential for advanced bionic applications and information encryption at room temperature.

Keywords:
ethanol responsivenessmechanical propertiessalt responsivenesssensing performancestimuli-responsive hydrogeltemperature response

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Area of Science:

  • Materials Science
  • Polymer Chemistry
  • Smart Materials

Background:

  • Stimuli-responsive hydrogels are crucial for bionic materials and AI.
  • Existing hydrogels often have limited response factors and poor responsiveness.
  • There is a need for advanced hydrogels with multi-stimuli responsiveness and conductivity.

Purpose of the Study:

  • To develop an ionically conductive hydrogel with multi-stimuli responsiveness.
  • To overcome limitations of single-response factors and poor responsiveness in current hydrogels.
  • To create a material for information encryption/decryption at room temperature.

Main Methods:

  • Synthesized a temperature/ethanol/salt stimuli-responsive conductive hydrogel (PPSD) via a one-pot method.
  • Utilized SDS, NIPAm, PVA, and SGA15 as raw materials in a salt solvent.
  • Incorporated SDS for low-temperature sensitivity and a high-temperature-sensitive monomer for dual-temperature response.

Main Results:

  • Achieved rapid dual-temperature responsiveness through controlled intermolecular interactions.
  • Demonstrated ethanol and salt stimuli-responsiveness via observable color changes due to disrupted intermolecular interactions and altered light scattering.
  • The hydrogel exhibited excellent sensing capabilities attributed to the directional migration of free ions.

Conclusions:

  • The developed PPSD hydrogel exhibits excellent transmission properties and multi-stimuli responsiveness.
  • This material shows promise for applications in bionic materials, AI, and information security.
  • The study highlights a novel approach to designing advanced stimuli-responsive conductive hydrogels.