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Related Experiment Video

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Treating venous malformations with nanomedicines.

Weimin Tang1,2, Daniel S Kohane1,3, Kathleen Cullion1,2

  • 1Laboratory for Biomaterials and Drug Delivery, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.

Nanomedicine (London, England)
|October 14, 2025
PubMed
Summary

Nanomedicine offers a novel approach for treating venous malformations (VMs) by using nanoparticles to target affected areas. Further research is needed to overcome challenges for safe and effective pediatric treatments.

Keywords:
Gold nanoparticlesNanoparticlesNanoshellsPediatricsTherapeutics

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Vascular Biology

Background:

  • Venous malformations (VMs) are congenital vascular anomalies causing pain and functional impairment.
  • Current therapies like sclerotherapy and surgery have limitations including complications and high recurrence rates.
  • Nanomedicine offers a promising alternative for targeted VM treatment.

Purpose of the Study:

  • To explore the potential of nanomedicine for treating venous malformations.
  • To review the application of nanoparticles (NPs) for drug delivery and non-pharmacologic therapies in VMs.
  • To identify challenges and future directions for clinical translation of nanomedicine in pediatric VMs.

Main Methods:

  • Review of preclinical studies on nanoparticle-based therapies for VMs.
  • Analysis of enhanced permeation and retention (EPR)-like effects for NP accumulation.
  • Evaluation of active targeting strategies using surface-functionalized NPs.
  • Assessment of challenges in clinical translation, including EPR heterogeneity and pediatric safety.

Main Results:

  • Nanoparticles can accumulate selectively in VMs via EPR-like effects.
  • NPs can be used for improved drug delivery and non-pharmacologic treatments like photothermal therapy.
  • Surface functionalization of NPs enhances targeting specificity and treatment efficacy.
  • Clinical translation is hindered by EPR variability, limited delivery depth, and pediatric safety concerns.

Conclusions:

  • Nanomedicine holds significant promise for developing safer, more efficient, and minimally invasive treatments for VMs.
  • Further development of pediatric-specific drug delivery systems is crucial.
  • Overcoming clinical translation challenges is essential for realizing the full potential of nanomedicine in VM therapy.