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Abnormal Proliferation02:23

Abnormal Proliferation

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Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
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Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

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Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
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DNA Damage can Stall the Cell Cycle02:36

DNA Damage can Stall the Cell Cycle

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In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...
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DNA Damage Can Stall the Cell Cycle02:36

DNA Damage Can Stall the Cell Cycle

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In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...
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Negative Regulator Molecules01:23

Negative Regulator Molecules

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Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.
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The Intrinsic Apoptotic Pathway01:31

The Intrinsic Apoptotic Pathway

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Internal cellular stress, such as cellular injury or hypoxia, triggers intrinsic apoptosis. The B-cell lymphoma 2 (Bcl-2) family of proteins are the primary regulators of the intrinsic apoptotic pathway. For example, during DNA damage, checkpoint proteins, such as Ataxia Telangiectasia Mutated (ATM protein) and Checkpoints Factor-2 (Chk2) proteins, are activated. These proteins phosphorylate p53 which further activates pro-apoptotic proteins, such as Bax, Bak, PUMA, and Noxa, and inhibits...
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Related Experiment Video

Updated: Jan 15, 2026

Yeast As a Chassis for Developing Functional Assays to Study Human P53
14:57

Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

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p53: An Immune Ecosystem Manipulator.

Zhigang Nian1,2,3, Yingchao Dou2,3, Haiming Wei1,2,3

  • 1Division of Life Sciences and Medicine, Department of Geriatrics, First Affiliated Hospital of USTC, University of Science and Technology of China, Hefei, China.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
|October 14, 2025
PubMed
Summary
This summary is machine-generated.

Mutations in the p53 tumor suppressor gene create an "immune barrier network," hindering immunotherapy effectiveness. Understanding this network is key to developing new combination cancer treatments.

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Purification of Ubiquitinated p53 Proteins from Mammalian Cells
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Last Updated: Jan 15, 2026

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Purification of Ubiquitinated p53 Proteins from Mammalian Cells
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Purification of Ubiquitinated p53 Proteins from Mammalian Cells

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Area of Science:

  • Oncology
  • Immunology
  • Cancer Genetics

Background:

  • Mutations in p53 are frequent in cancer, leading to loss of its tumor-suppressive functions.
  • p53 mutations significantly influence the tumor immune microenvironment, contributing to immunotherapy resistance.

Purpose of the Study:

  • To elucidate the mechanisms by which p53 mutations establish an immune barrier network.
  • To highlight the role of p53 as a mediator of immunotherapy resistance.

Main Methods:

  • Review of existing literature on p53 mutations and their impact on the tumor immune microenvironment.
  • Analysis of how p53 mutations modulate secretomes, immune ligands, antigen presentation, metabolism, and the extracellular matrix.

Main Results:

  • p53 mutations create an
  • immune barrier network
  • ,
  • This network involves modulation of cytokines, extracellular vesicles, immune ligands, antigen presentation, tumor metabolism, and the extracellular matrix.
  • p53 mutations act as critical mediators of resistance to cancer immunotherapy.

Conclusions:

  • Targeting the immune barrier network established by p53 mutations is a promising strategy for combination immunotherapy.
  • Future research should investigate mutant p53 subtypes, organ specificity, and their dual role in neoantigen generation and immune suppression.