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Blastoids for Modeling Early Embryonic Development: Application to Domestic Livestock.

Hao Ming¹, Jun Wu², Zongliang Jiang¹

¹Department of Animal Sciences, Genetics Institute, Institute of Food and Agricultural Sciences, University of Florida, Gainesville, Florida, USA;

Annual Review of Animal Biosciences

|October 14, 2025

Summary

Researchers are advancing stem cell technologies to create blastoids, which mimic early mammalian development. These models hold promise for improving livestock reproduction and understanding embryogenesis.

Keywords:

ARTs ESC TSC XEN assisted reproductive technologies blastocyst blastoid domestic livestock embryonic stem cell extraembryonic endoderm stem cell preimplantation development trophoblast stem cell

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Area of Science:

Developmental biology
Stem cell biology
Reproductive technologies

Background:

Stem cell technologies enable in vitro replication of embryogenesis.
Advances offer new insights into early mammalian development.
Novel assisted reproductive technologies (ARTs) are emerging.

Purpose of the Study:

Summarize current ARTs for animal reproduction.
Explore livestock embryo-based stem cell derivation.
Highlight blastoid generation breakthroughs.
Examine blastoid applications in domestic livestock.
Discuss challenges and future directions for blastoid models.

Main Methods:

Review of existing literature on assisted reproductive technologies.
Analysis of stem cell derivation techniques in livestock.
Evaluation of recent advancements in blastoid generation.
Exploration of potential applications and challenges of blastoid models.

Main Results:

Widely used ARTs for animal reproduction are summarized.
Progress in deriving embryo-based stem cells from livestock is detailed.
Latest breakthroughs in blastoid generation are highlighted.
Potential applications of blastoids in domestic livestock are examined.

Conclusions:

Blastoid models offer new frontiers in understanding mammalian embryogenesis.
These models show promise for novel assisted reproductive technologies.
Further development is needed to closely mimic natural embryonic development in livestock.