Blastoids for Modeling Early Embryonic Development: Application to Domestic Livestock

Recent advances in technologies that replicate specific aspects of embryogenesis in vitro by using stem cells have opened new frontiers in our understanding of the earliest steps of mammalian development and creation of promising novel assisted reproductive technologies (ARTs). We begin by summarizing the widely used ARTs in improving animal reproduction. We then explore current progress in deriving embryo-based stem cells from livestock species and highlight the latest breakthroughs in blastoid generation. Furthermore, we examine the potential applications of blastoids in domestic livestock and discuss key challenges and future directions for advancing blastoid models that closely mimic natural embryonic development.