Related Experiment Video
Updated: Jan 15, 2026
10:14
Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration
Published on: May 26, 2023
4.1K
OUTER RETINAL LAYER DETERIORATION PATTERNS IN EYES WITH DIABETIC SEROUS MACULAR DETACHMENT
Furkan Kirik1, M Giray Ersoz2, Furkan Atalay1
1Department of Ophthalmology, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Türkiye; and.
Retina (Philadelphia, Pa.)
|October 14, 2025
Summary
Diabetic macular detachment involves outer retinal layer deterioration patterns impacting vision. The WEDGE pattern shows better visual outcomes, while DIFFUSE patterns correlate with poorer prognosis.
Area of Science:
- Ophthalmology
- Retinal Imaging
- Diabetic Retinopathy
Background:
- Diabetic macular edema (DME) can lead to serous macular detachment (SMD).
- Outer retinal layer (ORL) integrity is crucial for visual function in DME patients.
- Understanding ORL deterioration patterns in diabetic SMD is essential for prognosis.
Purpose of the Study:
- Classify outer retinal layer (ORL) deterioration patterns in diabetic serous macular detachment (SMD).
- Determine the impact of these patterns on visual acuity and anatomical outcomes.
- Correlate specific ORL deterioration patterns with prognosis in diabetic SMD.
Main Methods:
- Retrospective case series analyzing optical coherence tomography (OCT) images.
- Identified five ORL deterioration patterns: DIFFUSE, PATCH, WEDGE, FISTULA, and SMD-DROL.
- Analyzed associations between patterns, best-corrected visual acuity (BCVA), and outer retinal layer integrity (external limiting membrane/ellipsoid zone).
Main Results:
- 168 of 1018 eyes showed ORL deterioration patterns.
- WEDGE pattern (31.75%) was most common and associated with better BCVA and less ELM/EZ alteration.
- DIFFUSE pattern (5.29%) was least common, observed in all eyes with ELM/EZ alterations, and linked to poorer visual outcomes.
Conclusions:
- Diabetic SMD exhibits diverse ORL deterioration patterns.
- These patterns are linked to varied clinical and anatomical prognoses.
- Identifying specific ORL patterns aids in predicting outcomes for diabetic SMD.
