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Updated: Jan 15, 2026

Efficient Synthesis of All-Carbon Quaternary Centers via the Conjugate Addition of Functionalized Monoorganozinc Bromides
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Extending the chemical space of glutarimide-based cereblon ligands through an efficient Rh(II)-catalyzed X-H

Ekaterina Levashova1, Luca Bischof2, Alexander Bunev3

  • 1Institute of Chemistry, Saint Petersburg State University, Saint Petersburg, Russia.

European Journal of Medicinal Chemistry
|October 14, 2025
PubMed

Keywords:
Cereblon ligandsCrystallographic analysisDiazo chemistryMicroscale thermophoresisNon-cytotoxic profileNovel binding modeQuantitative proteomics analysisX–H insertion

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