Radiotherapy for endometrial cancer: 2025 update

Area of Science:

• Oncology
• Radiation Oncology

Background:

• Surgery is the primary treatment for endometrial cancer.
• Radiotherapy (external beam and brachytherapy) is crucial in the adjuvant setting for managing locoregional recurrence risks based on histopathology.
• Radiotherapy also plays a role in treating inoperable endometrial tumors.

Purpose of the Study:

• To present the 2025 updated recommendations from the Société française de radiothérapie oncologique (SFRO) for endometrial cancer.
• To outline the indications for radiotherapy and brachytherapy in endometrial cancer management.
• To describe the technical methods for performing radiotherapy and brachytherapy for endometrial cancer.

Main Methods:

• The recommendations are based on a review of current evidence and expert consensus.
• The Société française de radiothérapie oncologique (SFRO) developed these updated guidelines.
• The focus is on indications and technical aspects of radiotherapy and brachytherapy.

Main Results:

• The updated guidelines provide a framework for using radiotherapy and brachytherapy in endometrial cancer.
• Specific indications are detailed based on histopathological risk factors and tumor operability.
• Technical considerations for delivering these radiation treatments are outlined.

Conclusions:

• The 2025 SFRO recommendations offer current best practices for radiotherapy and brachytherapy in endometrial cancer.
• These guidelines aim to optimize treatment strategies for improved patient outcomes.
• Adherence to these recommendations ensures appropriate use of radiation oncology modalities.