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Evaluation of a Reliable Biomarker in a Cecal Ligation and Puncture-Induced Mouse Model of Sepsis
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Biomarkers in sepsis: Less is more? Yes, it is

Gonçalo Guerreiro1, Pedro Póvoa2

  • 1Department of Critical Care Medicine, Unidade Local de Saúde Lisboa Ocidental, Lisbon, Portugal.

Intensive & Critical Care Nursing
|October 14, 2025
PubMed
Abstract

No abstract available in PubMed .

Keywords:
Antibiotic stewardshipBiomarkersC-reactive proteinClinical decision-makingProcalcitoninSepsis

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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
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