Associations between systemic inflammation response index and abdominal aortic calcification: a cross-sectional study

Area of Science:

• Cardiovascular Research
• Inflammation Biomarkers
• Public Health Nutrition

Background:

• Abdominal aortic calcification (AAC) is a marker of atherosclerosis.
• The Systemic Inflammation Response Index (SIRI) reflects systemic inflammation.
• The association between SIRI and AAC is not well understood.

Purpose of the Study:

• To investigate the relationship between SIRI and AAC.
• To evaluate SIRI's predictive value for severe AAC (SAAC).
• To compare SIRI with the Systemic Immune Inflammatory Index (SII) for SAAC prediction.

Main Methods:

• Analysis of the 2013-2014 National Health and Nutrition Examination Survey (NHANES) cohort (n=3,047).
• Quantification of AAC and SAAC using the Kauppila scoring system.
• Multivariate regression and ROC curve analysis to assess SIRI's association and predictive value.

Main Results:

• A significant positive association was found between SIRI and AAC scores.
• Higher SIRI quartiles correlated with increased AAC scores and SAAC prevalence.
• SIRI demonstrated superior predictive value for SAAC compared to SII.

Conclusions:

• Elevated SIRI is associated with increased abdominal aortic calcification.
• SIRI serves as a valuable predictor for severe abdominal aortic calcification.
• SIRI may offer a novel biomarker for cardiovascular risk assessment.