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Characteristics of lipid metabolism dysfunction in hypertensive disorders of pregnancy

Zizhuo Wang1,2, Liangnan Zhang1,2, Xuan Zhou1,2

  • 1National Clinical Research Center for Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.

BMC Pregnancy and Childbirth
|October 14, 2025
PubMed

Insights

Hypertensive disorders of pregnancy (HDP) show altered lipid metabolism, especially fatty acids (FAs), linked to clinical features. MCAM and MAPK pathways may play roles in HDP pathogenesis.

Area of Science:

  • Obstetrics and Gynecology
  • Metabolomics
  • Molecular Biology

Background:

  • Hypertensive disorders of pregnancy (HDP) are major causes of maternal and perinatal morbidity.
  • Lipid metabolism dysfunction is implicated in HDP, but its specific characteristics are unclear.

Purpose of the Study:

  • To investigate lipid metabolism dysfunction in HDP.
  • To identify molecular pathways involved in HDP-related lipid dysregulation.

Main Methods:

  • Full-spectrum metabolomic profiling of blood samples from 30 HDP patients and 30 controls.
  • Targeted metabolic validation in placental tissues.
  • RNA sequencing to analyze gene expression related to lipid metabolism.

Main Results:

  • Significant disruptions in fatty acyl (FA) metabolism observed in HDP patients.
  • Specific FA levels correlated with HDP clinical characteristics.
  • MCAM expression linked to FA metabolism and HDP symptoms; MAPK pathway activation suggested.

Conclusions:

  • Provides insights into lipid metabolism dysfunction in HDP.
  • Delineates potential molecular pathways involving MCAM and MAPK in HDP pathogenesis.
Abstract

Keywords:
Full-spectrum metabolomic profilingHypertensive disorders of pregnancyLipid metabolism dysfunctionMCAM

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