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Related Concept Videos

Depressive Disorders: Etiology01:27

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Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
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Related Experiment Video

Updated: Jan 15, 2026

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
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Depression with risks for spontaneous abortion: a meta-analysis.

Junxiu Liu1, Mingyang Zhao1, Jia Zhuan1

  • 1Department of Gynecology, Cangzhou People's Hospital, 7 Qingchi Avenue, Xinhua District, Cangzhou City, Hebei Province, China.

BMC Psychology
|October 15, 2025
PubMed
Summary

Women experiencing depression face a higher risk of spontaneous abortion (SA). This association between depression and SA risk is independent of antidepressant medication use.

Keywords:
DepressionMeta-analysisRisksSpontaneous abortion

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Area of Science:

  • Reproductive Health
  • Mental Health
  • Epidemiology

Background:

  • Depression is a prevalent mental health condition affecting women of reproductive age.
  • Spontaneous abortion (SA) is a common adverse pregnancy outcome.
  • Understanding risk factors for SA is crucial for improving maternal and child health outcomes.

Purpose of the Study:

  • To evaluate the association between maternal depression and the risk of spontaneous abortion.
  • To synthesize evidence from multiple studies on depression and SA risk.

Main Methods:

  • A comprehensive literature search was conducted across PubMed, Web of Science, and Embase databases.
  • Meta-analysis using a random-effects model was employed to pool data.
  • Relative risk (RR) with 95% confidence intervals (95% CI) were calculated to quantify the association.

Main Results:

  • The meta-analysis included 31 studies comprising 8,919,953 women.
  • A significant association was found between depression and an increased risk of spontaneous abortion (RR = 1.34, 95% CI [1.27, 1.41]).
  • Sensitivity and subgroup analyses confirmed the robustness of the findings, with low risk of bias detected.

Conclusions:

  • Women with depression exhibit an elevated risk of spontaneous abortion compared to women without depression.
  • This increased risk of SA in women with depression is not influenced by the use of antidepressant medications.