Association between pulmonary function tests and lipid levels
Kadriye Akpinar1,2, Alev Lazoğlu Özkaya3
1Biochemistry Laboratory, Ministry of Health, Burdur State Hospital, Burdur, Türkiye.
Medicine
|October 15, 2025
Summary
Age and sex significantly impact pulmonary function, with older individuals and females showing reduced lung capacity. While smoking and metabolic factors like HbA1c and lipids show complex associations, they were not independently significant predictors.
Area of Science:
- Pulmonary Medicine
- Clinical Biochemistry
- Health Sciences
Background:
- Pulmonary function tests (PFTs) assess lung health, while biochemical markers like lipids, glucose, and HbA1c indicate metabolic status.
- Obesity, diabetes, and smoking are known risk factors for various health conditions, potentially affecting lung function.
- The monocyte-to-HDL ratio (MHR) is an emerging marker of inflammation and cardiovascular risk.
Purpose of the Study:
- To investigate the association between PFTs and biochemical parameters (lipids, MHR, glucose, HbA1c) in individuals undergoing routine health checkups.
- To identify demographic and clinical factors influencing pulmonary function and biochemical markers.
Main Methods:
- Analysis of PFTs (spirometry) and biochemical parameters (cholesterol, LDL, HDL, TG, glucose, HbA1c, monocyte count) in 153 subjects.
- Comparison of PFTs and biochemical markers across groups based on body mass index, diabetes status, lipid levels, smoking status, sex, and age.
- Multivariable regression analysis to determine independent predictors of pulmonary function.
Main Results:
- Overweight/obese and diabetic/prediabetic individuals exhibited significantly higher glucose, HbA1c, and lipid levels compared to controls.
- Smokers and males showed significantly higher MHR compared to nonsmokers and females, respectively.
- Smokers and females demonstrated significantly lower forced vital capacity (FVC) and forced expiratory volume in 1 second (FEV1) compared to nonsmokers and males, respectively.
- Older age and male sex were independently associated with reduced FVC and FEV1.
Conclusions:
- Age and sex are significant determinants of pulmonary function.
- While smoking, body mass index, HbA1c, and lipid levels show associations with pulmonary function, their independent contributions are complex and warrant further investigation.
- The study highlights the interplay between metabolic health, lifestyle factors, and lung function.
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