Shear Wave Elastography-Based Quantitative Assessment of Carotid Artery Elasticity in Uremic Patients With Different
Xinyao Wang1, Dongmei Huang1, Hongyan Cui1
1Department of Ultrasound, The Second Affiliated Hospital of Dalian Medical University, Dalian, China.
Objective:
To investigate the potential clinical value of shear wave elastography (SWE) for quantitatively assessing carotid artery elasticity in uremic patients with different left ventricular configurations.
Methods:
According to different left ventricular configurations, 133 patients diagnosed with uremia were divided into four groups: group B (normal configuration, NG, n = 37), group C (centripetal remodeling, CR, n = 37), group D (centripetal hypertrophy, CH, n = 38), and group E (eccentric hypertrophy, EH, n = 21). Additionally, a control group (group A) consisting of 40 healthy volunteers was selected. None of the subjects exhibited plaque formation in their carotid arteries. Conventional carotid ultrasound was used to assess the intima-media thickness (IMT), peak systolic velocity (PSV), and the systolic and diastolic diameters (Ds and Dd) of the left common carotid artery. Moreover, the wall motion degrees (ΔD) and arterial stiffness coefficient (β) were calculated. The maximum elastic modulus (MEmax), mean elastic modulus (MEmean), and minimum elastic modulus (MEmin) of the carotid artery anterior wall intima-media were obtained using SWE.
Results:
Compared with group A, the IMT and β values in groups B and C were increased; however, the differences among the three groups were not statistically significant (p > 0.05). In contrast, groups D and E exhibited markedly elevated IMT and β values, which were significantly different from those in groups A, B, and C (p < 0.05). Groups B through E exhibited significantly elevated MEmax, MEmean, and MEmin values in comparison to group A. Statistically significant intergroup differences were identified (p < 0.05), reflecting a stepwise increase in the order of E > D > C > B > A. The linear regression analysis revealed a statistically significant association between different left ventricular configurations and SWE parameters in patients with uremia (p < 0.05).
Conclusion:
SWE can quantitatively assess carotid artery elasticity in uremic patients with different left ventricular configurations.
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