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Endocarditis II: Clinical Features of Infective Endocarditis01:25

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Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
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The cranial and spinal meninges are complex protective structures surrounding the central nervous system (CNS), consisting of the brain and spinal cord. These meninges consist of the dura mater, the arachnoid mater, and the pia mater. They protect the CNS, provide structural support, and aid in circulating cerebrospinal fluid (CSF).
Cranial Meninges
These meningeal layers cover the cranium. The dura mater is the outermost layer of cranial meninges. It is a thick and durable membrane of dense...
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Fungal Phylum Microsporidia01:28

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Microsporidia are a group of obligate intracellular fungi that were initially classified as protists but were later reclassified based on phylogenetic, molecular, and structural evidence linking them to the Chytridiomycota. These unicellular, non-motile organisms are highly specialized parasites that infect a wide range of animal hosts, including humans. They have evolved extensive genomic and metabolic reductions, making them highly dependent on their hosts for survival.Morphology and Genomic...
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Cryptococcal Meningitis Without Headache: A Case Report Highlighting an Atypical Presentation.

Yvanne Joshua Rabe1,2, Ailleen M Villegas1, Valmarie S Estrada3,4

  • 1Section of Adult Neurology, Department of Internal Medicine, Cardinal Santos Medical Center, San Juan, PHL.

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|October 15, 2025
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Summary

Cryptococcus neoformans meningoencephalitis, a serious fungal infection, can occur in immunocompromised patients. Early central nervous system (CNS) evaluation is vital, even without typical symptoms, for timely diagnosis and treatment.

Area of Science:

  • Infectious Diseases
  • Mycology
  • Neurology
Keywords:
atypical presentationcryptococcal meningitisdisseminated cryptococcal infectionheadache absencesteroid treatment

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Background:

  • Cryptococcus neoformans meningoencephalitis is a frequent complication in immunocompromised individuals, including those with acquired immunodeficiency syndrome (AIDS).
  • Immunosuppression can result from glucocorticoid therapy, organ transplantation, or malignancies, increasing susceptibility to disseminated fungal infections.
  • Typical symptoms include headache, fever, vomiting, and altered mental status, but these may be absent or masked in certain patient populations.