Related Experiment Video
Updated: Jan 15, 2026
Isolation of Adipose Derived Regenerative Cells for the Treatment of Erectile Dysfunction Following Radical Prostatectomy
Published on: December 28, 2021
Enhancing penile function: the impact of a regenerative multimodal protocol on erectile dysfunction
Andrés Soto-Rodríguez1, Carla Pastora-Sesín1, Juan Antonio Valverde-Espinoza1,2
1Research Unit, The Regenerative Medicine Institute, San José, Costa Rica.
Background:
Erectile dysfunction (ED) is a prevalent condition impacting men's quality of life and is often linked to cardiovascular and metabolic disorders. Conventional treatments like phosphodiesterase type 5 (PDE5) inhibitors could be ineffective for severe cases, indicating a need for innovative approaches. This study aimed to evaluate the efficacy and safety of a multimodal protocol combining low-intensity shockwave therapy (LiST), intrapenile and intravenous umbilical cord-mesenchymal stem cell (UC-MSCs) therapy, and hyperbaric oxygen therapy (HBOT) in men with ED. A retrospective pragmatic observational study was performed by reviewing medical records of 22 men treated at a private clinic in Costa Rica. Erectile function was measured using the Sexual Health Inventory for Men (SHIM) questionnaire before treatment and three months post-treatment.
Results:
The protocol significantly improved SHIM scores, with a mean increase of 3 points from baseline (p = 0.0017). No major adverse events were reported during follow-up.
Conclusion:
The multimodal protocol demonstrated a significant improvement in erectile function with a favorable safety profile, suggesting potential as a viable option for patients with ED. Further prospective randomized controlled trials are needed to validate these findings.
