Related Experiment Video
Updated: Jan 15, 2026
06:31
Identification and Dissection of Diverse Mouse Adipose Depots
Published on: July 11, 2019
44.6K
Fat talks first: how adipose tissue sets the pace of aging?
Juanhong Liu1, Qinlei Huang1, Feng Liu1
1National Clinical Research Center for Metabolic Diseases, Metabolic Syndrome Research Center, The Second Xiangya Hospital of Central South University, Changsha 410000, China.
Life Medicine
|October 15, 2025
Summary
Adipose tissue, once seen as just fat storage, is now known to drive aging. Understanding its dysfunction offers new ways to promote healthy aging.
Area of Science:
- Aging Biology
- Endocrinology
- Metabolic Health
Background:
- Adipose tissue (AT) is increasingly recognized as a crucial endocrine organ influencing systemic aging.
- Age-related changes in AT include altered fat distribution, visceral expansion, impaired thermogenesis, and chronic inflammation, disrupting homeostasis.
Purpose of the Study:
- To review the role of adipose tissue as both a sensor and driver of aging.
- To discuss therapeutic strategies targeting adipose dysfunction for healthy aging.
Main Methods:
- Review of current literature.
- Analysis of insights from single-cell and spatial transcriptomics.
Main Results:
- Adipose tissue undergoes significant remodeling with age, contributing to local dysfunction and systemic decline.
- Dysfunctional adipose tissue drives age-related pathologies via inflammatory and metabolic signaling.
Conclusions:
- Adipose tissue plays a pivotal role in the aging process.
- Targeting adipose tissue dysfunction presents promising therapeutic avenues for promoting healthy aging.
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