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Predictive Value of Combined CRP and INR for Intracranial Hypertension in Cerebral Venous Thrombosis

Jiahui Yan1, Manli Lu1, Zhichao Huang1

  • 1Department of Neurology and Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, China.

Immunity, Inflammation and Disease
|October 15, 2025
PubMed

Insights

Cerebral venous thrombosis (CVT) patients with high C-reactive protein (CRP) or low international normalized ratio (INR) face increased intracranial hypertension (IH) risk. Combining CRP and INR offers a noninvasive method for assessing IH in CVT.

Area of Science:

  • Neurology
  • Vascular Medicine
  • Biomarker Research

Background:

  • Intracranial hypertension (IH) is a significant indicator of severity in cerebral venous thrombosis (CVT).
  • Current gold standard for measuring intracranial pressure (ICP) involves invasive lumbar puncture.
  • There is a need for noninvasive methods to assess IH in CVT patients for early risk stratification.

Purpose of the Study:

  • To develop a noninvasive predictive model for IH in CVT patients.
  • To integrate clinical features and biomarkers for improved IH risk assessment.
  • To facilitate early risk stratification and management of CVT patients.

Main Methods:

  • Consecutive enrollment of CVT patients from January 2011 to June 2024.
  • Classification of patients into CVT-IH and CVT+IH groups based on ICP levels.
  • Logistic regression analysis using C-reactive protein (CRP) and international normalized ratio (INR) levels, categorized by ROC curves, to determine IH risk.

Main Results:

  • 157 patients were included; 61 presented with IH.
  • Elevated CRP (>5.5 g/L) or low INR (<0.99) significantly correlated with higher IH incidence.
  • A combination of high CRP and low INR increased IH risk by 9.778 times; adding CRP and INR improved IH prediction accuracy in CVT patients.

Conclusions:

  • The combined use of CRP and INR effectively predicts IH occurrence in CVT patients.
  • This biomarker combination offers a potential noninvasive approach for assessing ICP in CVT.
  • Early identification of IH risk in CVT patients can be enhanced through this noninvasive model.
Abstract

Keywords:
C‐reaction proteincerebral venous thrombosiscombined effectinternational normalized ratiointracranial hypertension

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