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Updated: Jan 15, 2026

Efficient Synthesis of Polyfunctionalized Benzenes in Water via Persulfate-promoted Benzannulation of α,β-Unsaturated Compounds and Alkynes
Published on: December 16, 2019
Silver-catalyzed synthesis of polyfunctionalized 1,7- and 2,7-benzonaphthyridine scaffolds and access to perlolidine
Kirti Vashishtha1,2,3, Kapil Chahal1,3, Namita Bhoi1
1Catalysis and Fine Chemicals Division, CSIR Indian Institute of Chemical Technology, Tarnaka, Hyderabad-500007, Telangana, India. rajender.iict@csir.res.in.
Abstract:
A regio- and chemoselective silver-catalyzed one-pot synthesis of benzo[b][1,7]- and benzo[c][2,7]-naphthyridines has been developed via a sequential Michael addition and silver-mediated cyclization strategy. The protocol exhibits excellent selectivity, high yields, and broad functional group tolerance. The resulting polyfunctionalized benzo[c][2,7]-naphthyridine scaffolds were further investigated as key intermediates toward the synthesis of perlolidine analogues, highlighting their potential for the discovery of novel bioactive compounds and alkaloid frameworks.
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