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Published on: July 19, 2012
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Ocular Motor Abnormalities in Functional Neurological Disorder: A Video-Oculography Study
Aude Sangare1,2, Astrid de Liège3, Bertrand Gaymard1
1Department of Neurophysiology, Assistance Publique-Hôpitaux de Paris, Pitié-Salpêtrière Charles Foix Hospital Group, DMU Neurosciences, Sorbonne University, Paris, France.
Movement Disorders Clinical Practice
|October 15, 2025
Summary
Video-oculography reveals distinct eye movement patterns in functional neurological disorders (FND). These oculomotor findings, including increased saccade latency and hypometric vertical saccades, may aid in FND diagnosis.
Area of Science:
- Neurology
- Ophthalmology
- Biomarker Research
Background:
- Functional neurological disorders (FND) present with diverse sensory, motor, and cognitive symptoms.
- Video-oculography offers potential as a biomarker for characterizing FND-related dysfunctions.
Purpose of the Study:
- To identify specific oculomotor patterns indicative of FND.
- To assess the diagnostic utility of eye movement recordings in FND.
Main Methods:
- Retrospective analysis of video-oculography data from 149 FND patients (2011-2023).
- Comparison with 132 healthy controls and 43 multiple sclerosis (MS) patients.
- Focus on horizontal/vertical prosaccades, smooth pursuit, and antisaccades.
Main Results:
- FND patients showed significantly increased saccade latencies (horizontal and vertical) versus controls (P < 0.0001).
- Greater saccade latency variability observed in FND compared to control and MS groups (P < 0.0001).
- FND patients exhibited hypometric vertical saccades and increased variability in upward saccade amplitude (P < 0.0001).
- Both FND and MS groups had higher antisaccade error rates than controls (P < 0.0001).
Conclusions:
- Video-oculography data suggest specific oculomotor abnormalities in FND.
- These findings support video-oculography as a valuable tool for understanding FND pathophysiology.
- Eye movement analysis shows potential as a complementary diagnostic aid for FND.
