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A Change of Hallmark: An Update
Tom Donnem1,2, David Kerr3, Leonid L Nikitenko4
1Department of Oncology, University Hospital of North Norway, N-9038 Tromso, Norway.
Cells
|October 15, 2025
Summary
This review covers recent advancements in non-angiogenic tumors, focusing on primary and metastatic cancers in organs like the lung and liver. It also discusses limited treatment progress and new techniques for these rare tumor types.
Area of Science:
- Oncology
- Cancer Biology
Background:
- The modified hallmarks of cancer include inducing angiogenesis and accessing vessels.
- Non-angiogenic tumors represent a distinct category of neoplastic growth.
- Understanding these tumors is crucial for comprehensive cancer research.
Purpose of the Study:
- To review the latest developments in non-angiogenic tumors over the past three years.
- To examine primary and metastatic tumors in various organs (lung, liver, brain).
- To discuss advancements in treatment and techniques for non-angiogenic tumors.
Main Methods:
- Literature review focusing on the last three years.
- Inclusion of rarer tumors with older literature.
- Categorization of tumors by primary site and metastatic potential.
Main Results:
- Review of primary and metastatic tumors in lung, liver, and brain.
- Discussion of oral cancer, lymphomas, and node metastasis.
- Limited progress in treatment strategies for non-angiogenic tumors.
Conclusions:
- Non-angiogenic tumors present unique challenges in oncology.
- Further research is needed to improve treatment outcomes.
- Advancements in understanding tumor biology are ongoing.
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