Magnetic slippery microcatheter with artificial cilia for low-friction interventions

Area of Science:

• Biomedical Engineering
• Materials Science
• Minimally Invasive Medicine

Background:

• Medical catheters are crucial for minimally invasive procedures but can damage fragile tissues due to rigidity.
• Existing catheter designs face challenges in navigating complex anatomical pathways safely and effectively.

Purpose of the Study:

• To develop a novel microcatheter with enhanced flexibility and reduced friction for safer and more effective minimally invasive procedures.
• To investigate the potential of magnetically actuated artificial cilia for improved catheter navigation.

Main Methods:

• Development of a liquid-infused slippery microcatheter (LISMC) incorporating soft magnetic artificial cilia inspired by foxtail grass.
• Utilizing magnetic actuation for cilium oscillation to enhance adaptability and reduce friction during navigation.
• Proof-of-concept demonstration involving deployment and actuation of microswimmers in rabbit bile ducts for x-ray-guided treatment.

Main Results:

• The LISMC demonstrated a two-thirds reduction in friction compared to conventional designs.
• Magnetic cilia oscillation facilitated smooth traversal and adaptability in complex luminal pathways.
• Successful precision deployment and downstream actuation of microswimmers for treating acute pancreatitis in rabbit models.

Conclusions:

• The magnetically actuated LISMC represents a significant advancement in interventional medicine, offering a safer and more adaptable tool.
• This technology provides a scalable platform for next-generation therapeutic applications in complex anatomical environments.
• The LISMC design minimizes mechanical forces on tissues, reducing the risk of complications during procedures.