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Updated: May 2, 2026

Engineered Vascularized Muscle Flap
Published on: January 11, 2016
Optimizing limb salvage in critical mangled extremities: one-step acute repair with bilateral anterolateral thigh
Yining Lan1,2, Luqi Guo1, Dedi Tong3
1Department of Plastic and Reconstructive Surgery, Chinese Academy of Medical Science Peking Union Medical College Hospital, Beijing, China.
Background/Objectives:
Complex distal extremity trauma often involves both extensive soft tissue loss and vascular injury. While the anterolateral thigh (ALT) free flap is a mainstay for limb salvage, large defects may exceed the capacity of a single flap and are associated with higher complication rates. We report a one-stage bilateral ALT free-flap reconstruction strategy designed to provide stable wound coverage and improve functional outcomes.
Methods:
In six patients with severe distal extremity trauma (affecting upper or lower limbs) treated from 2018 to 2020, one-stage reconstruction was performed using bilateral ALT free flaps. Flaps were inset via tandem or parallel vascular configurations based on recipient vessel status. Functional outcomes were assessed by Disabilities of the Arm, Shoulder and Hand scores (upper limbs) or Lower Extremity Functional Scale (lower limbs) with 5 years of follow-up. Four patients had postoperative photon-counting computed tomography (PCCT) angiography to assess anastomotic patency.
Results:
All flaps survived without major complications. By the final follow-up, all patients had achieved stable soft-tissue coverage and satisfactory functional recovery. Functional outcome scores improved in every case, and notably, the pediatric patient attained normal gait and limb development after reconstruction. The four patients who underwent PCCT angiography were confirmed patent anastomoses and robust perfusion.
Conclusions:
One-stage bilateral ALT free-flap reconstruction is a safe and feasible approach for complex distal extremity trauma. It provides reliable wound coverage and facilitates timely functional recovery while avoiding the morbidity of staged procedures. Long-term outcomes demonstrate sustained flap viability and functional gains, supporting this approach to avoid staged procedures and improve limb salvage.
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