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Updated: Jan 15, 2026
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In Vitro Model of Human Cutaneous Hypertrophic Scarring using Macromolecular Crowding
Published on: May 1, 2020
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Skin microbiota, immune phenotypes, inflammatory response and hypertrophic scars: A Mendelian randomization study
Yutang Li1, Li Tang2, Yiyi He1
1Department of Burns, The First hospital of Jilin University, Changchun 130021, China.
Burns : Journal of the International Society for Burn Injuries
|October 15, 2025
Summary
The skin microbiome influences hypertrophic scars (HS) through immune responses and inflammation. Certain immune factors act as key mediators, clarifying the causal link between skin bacteria and scar development.
Area of Science:
- Dermatology
- Microbiology
- Immunology
- Genetics
Background:
- Emerging evidence suggests a connection between skin microbiota and hypertrophic scars (HS).
- The precise causal mechanisms and the role of immune responses in this relationship remain unclear.
Purpose of the Study:
- To investigate the causal effects of skin microbiota on HS.
- To explore the mediating roles of cytokines and immune phenotypes in the skin microbiota-HS axis.
Main Methods:
- Genome-wide association study (GWAS) and Mendelian randomization (MR) analyses were employed.
- Inverse variance weighting (IVW) was the primary statistical method.
- Mediation analyses assessed the role of immune factors.
Main Results:
- Identified significant causal effects between specific skin microbiota and HS.
- Found causal links between several cytokines, immune phenotypes, and HS.
- Discovered inflammatory factors and immune phenotypes acting as mediators between skin microbiota and HS.
Conclusions:
- The skin microbiome, immune system, and inflammatory responses are causally associated with HS.
- Specific immune phenotypes and inflammatory factors mediate the link between skin microbiota and hypertrophic scar formation.
