Related Experiment Video
Updated: Jun 21, 2026
Evaluation of a Novel Laser-assisted Coronary Anastomotic Connector - the Trinity Clip - in a Porcine Off-pump Bypass Model
Published on: November 24, 2014
Association Between Angiography-Derived Murray Law-Based Quantitative Flow Ratio and 1-Year Coronary Artery Bypass
Ho Young Hwang1, Daixin Ding2, Jeehoon Kang3
1Department of Thoracic and Cardiovascular Surgery, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.
Insights
The quantitative flow ratio (μFR) can predict 1-year graft patency after coronary artery bypass grafting (CABG). An optimal cutoff value of 0.77 for μFR indicates significant coronary artery stenosis impacting CABG outcomes.
Area of Science:
- Cardiovascular Surgery
- Interventional Cardiology
- Medical Imaging
Background:
- Limited studies exist on the impact of functional significance of coronary artery stenosis on coronary artery bypass grafting (CABG) outcomes.
- Decision-making based on stenosis severity is crucial for CABG success.
Purpose of the Study:
- To evaluate the predictive value of preoperative quantitative flow ratio (μFR) for 1-year graft patency after CABG.
- To assess the functional significance of coronary artery stenosis using Murray law-based μFR.
Main Methods:
- Retrospective analysis of 809 patients undergoing isolated off-pump CABG for 3-vessel disease.
- Preoperative μFR data collected for feasible target vessels.
- Generalized linear mixed-effects models and minimal P value approach used for analysis.
Main Results:
- 1-year graft occlusion rate was 5.1%.
- μFR was significantly associated with 1-year graft patency (OR: 0.847; P=0.03), but not early patency.
- Optimal predictive cutoff for μFR was identified as 0.77.
Conclusions:
- Preoperative μFR is a significant predictor of 1-year graft patency post-CABG.
- An optimal μFR cutoff of 0.77 effectively identifies functionally significant stenosis.
- This finding aids in optimizing decision-making for CABG procedures.
Background:
Studies evaluating the impact of functional significance of coronary artery stenosis-based decision-making on results after coronary artery bypass grafting (CABG) are limited.
Objectives:
This study was conducted to evaluate the predictive value of preoperative angiography-derived Murray law-based quantitative flow ratio (μFR) of target native coronary arteries on 1-year graft patency following CABG.
Methods:
A total of 809 patients who underwent isolated off-pump CABG for 3-vessel disease and 1-year graft evaluation were retrospectively enrolled. Preoperative μFR data were obtained for all feasible target vessels. Multivariable analyses were conducted using generalized linear mixed-effects models. The minimal P value approach was used to determine the optimal cutoff value of the μFR that predicting graft patency.
Results:
The mean age of the study population was 65.9 ± 9.0 years. A total of 2,324 distal anastomoses were included in the analysis. Early and 1-year graft occlusion rates were 0.8% (19 of 2,324 anastomoses; 95% CI: 0.5-1.3 anastomoses) and 5.1% (118 of 2,324 anastomoses; 95% CI: 4.2-6.1 anastomoses), respectively. Multivariable analysis demonstrated that μFR was significantly associated with 1-year graft patency (OR [95% CI]: 0.847 [0.731-0.982]; P = 0.03), but not with early graft patency (0.941 [0.746-1.186]; P = 0.60). The minimal P value approach identified μFR values between 0.75 and 0.78 having the strongest discriminative power, with the lowest P value at a μFR of 0.77.
Conclusions:
The functional significance of coronary artery stenosis of target vessels, as measured by μFR, is associated with 1-year graft patency after off-pump CABG with an optimal cutoff value of 0.77 (Association Between ΜFR and CABG Outcomes; NCT06844721).
