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Related Experiment Video

Updated: Jan 15, 2026

Subcutaneous Neurotrophin 4 Infusion Using Osmotic Pumps or Direct Muscular Injection Enhances Aging Rat Laryngeal Muscles

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Assessing Injectate Volume in Injection Laryngoplasty Using Low-Cost Handheld Ultrasonography: Feasibility Study in

Mark Lee¹, Christine M Clark¹, Sarah R Kervin¹

¹Sean Parker Institute for the Voice, Department of Otolaryngology-Head and Neck Surgery, Weill Cornell Medicine, New York, New York.

Journal of Voice : Official Journal of the Voice Foundation

|October 15, 2025

Summary

Low-cost handheld ultrasound can measure injected material volumes in vocal fold augmentation. This technology may aid clinical decisions regarding injection laryngoplasty (IL) and subsequent procedures.

Keywords:

Handheld ultrasound Injection laryngoplasty Office procedure Vocal fold paralysis

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Published on: June 28, 2024

Area of Science:

Laryngology
Medical Ultrasound
Biomaterials

Background:

Injection laryngoplasty (IL) is used for vocal fold augmentation.
Accurate measurement of injected material volume is crucial for IL outcomes.
Current methods for volume assessment can be imprecise.

Purpose of the Study:

To evaluate the feasibility of using low-cost handheld ultrasound to measure injected material volumes in vocal folds.
To assess the correlation between injected volume and ultrasound-measured cross-sectional area.

Main Methods:

A feasibility study using an ex vivo porcine model.
Injection of two volumes (0.375 mL, 0.75 mL) of hyaluronic acid (HA) and calcium hydroxyapatite (CaHA) into porcine vocal folds.
Ultrasound measurement of cross-sectional area and ANCOVA for correlation analysis.

Main Results:

Ultrasound successfully visualized HA and CaHA injections in porcine vocal folds.
Measured cross-sectional area significantly increased with larger injection volumes (P=0.0151).
Material type did not significantly impact measured area or its relation to injected volume.

Conclusions:

Handheld ultrasound shows feasibility for assessing injectate volume in vocal fold augmentation.
This technique could inform clinical decisions, such as timing of thyroplasty post-IL.
Further clinical studies are needed to validate its utility for voice outcomes.