Related Experiment Video
Updated: Jan 15, 2026
07:21
Microsurgical Creation of Giant Bifurcation Aneurysms in Rabbits for the Evaluation of Endovascular Devices
Published on: September 8, 2023
1.0K
Flow Diversion versus Coiling with or without Stenting for Unruptured Wide-Neck Intracranial Aneurysms: A Randomized
William Boisseau1, Xavier Combaz2, Olivier Levrier2
1From the Interventional Neuroradiology Department (W.B., S.S., S.E., M.P.), Fondation Adolphe de Rothschild, Paris, Ile de France, France.
AJNR. American Journal of Neuroradiology
|October 15, 2025
Summary
Flow diversion (FD) was not superior to coiling with or without stenting for treating wide-necked unruptured intracranial aneurysms (UIAs). This randomized trial found similar treatment failure rates between the two methods for these specific aneurysms.
Area of Science:
- Neurology
- Interventional Neuroradiology
- Neurosurgery
Background:
- Unruptured intracranial aneurysms (UIAs) pose a significant risk.
- Wide-necked UIAs present unique treatment challenges.
- Limited randomized data exists comparing Flow Diversion (FD) and coiling strategies.
Purpose of the Study:
- To compare the efficacy and safety of FD versus coiling (with or without stenting) for wide-necked UIAs.
- To evaluate treatment failure rates at 12 months post-intervention.
- To assess serious adverse events in both treatment groups.
Main Methods:
- Investigator-led, randomized (1:1) trial across 7 French university hospitals.
- Included patients with 7-20mm intradural UIAs, 4-10mm neck, and dome/neck ratio ≥1.
- Primary outcome: composite of treatment failure (initial, rupture, retreatment, death/dependency, residual aneurysm).
Main Results:
- 87 patients analyzed (43 FD, 44 coiling).
- Most had small (<10mm) asymptomatic ophthalmic aneurysms.
- Treatment failure rates were similar: 18.6% (FD) vs. 23.3% (coiling), p=0.60.
- Serious adverse events were comparable between groups.
Conclusions:
- Flow diversion (FD) is not superior to coiling with or without stenting for wide-necked ophthalmic aneurysms <10mm.
- Both treatment modalities demonstrated comparable safety profiles.
- Further research may be needed for different aneurysm subtypes or sizes.
