Anemia of Prematurity in an ELBW Neonate of Jehovah's Witness Parents
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Updated: Jan 15, 2026

Biochemical Measurement of Neonatal Hypoxia
Published on: August 24, 2011
Lauren M McCotter1, Amy J Jnah2
1Department of Advanced Practice Nursing Practice and Education, East Carolina University College of Nursing, Greenville, NC, USA mccotterl22@students.ecu.edu.
Insights
Anemia of prematurity affects premature infants due to decreased red blood cell mass. This case highlights ethical dilemmas when Jehovah
Area of Science:
- Neonatal Medicine
- Pediatric Hematology
Background:
- Anemia of prematurity is a common complication in preterm infants, linked to gestational age and medical interventions.
- Severity correlates with gestational age, comorbidities affecting erythropoiesis, and frequent blood draws.
- Blood transfusions are standard treatment but raise ethical concerns for specific religious groups.
Purpose of the Study:
- To present a case study of anemia of prematurity in an infant born to Jehovah's Witness parents.
- To discuss the pathophysiology and clinical presentation of anemia in preterm infants.
- To explore the ethical and legal challenges faced by healthcare providers when families refuse life-saving blood transfusions.
Main Methods:
- Case study of a 24-week gestation infant.
- Review of the pathophysiology of anemia of prematurity.
- Discussion of clinical manifestations and management considerations.
Main Results:
- The case involved a preterm infant with anemia of prematurity whose parents, adhering to Jehovah's Witness beliefs, refused blood transfusions.
- The study details the infant's condition, emphasizing the challenges in managing anemia in this context.
- Pathophysiology and clinical signs of anemia in premature infants are described.
Conclusions:
- Managing anemia of prematurity in infants of parents with religious objections to blood transfusions presents significant ethical and legal challenges.
- Healthcare providers must navigate complex decisions balancing infant well-being with parental rights and beliefs.
- Further discussion and guidelines are needed for such complex ethical scenarios in neonatal care.
Abstract:
Anemia of prematurity is a physiologic and iatrogenic process defined by gestational age and involves a decrease in an infant's red blood cell mass by 2 SD Severity is often inversely proportional to gestational age and the presence of comorbid conditions that alter erythropoietin production, reduce red blood cell life span and iron stores, and necessitate frequent serum blood draws. Blood transfusion is a common treatment for severe anemia, and when nonemergent it requires informed consent from a parent or a court-appointed guardian. Jehovah's Witness (JW) community members typically do not accept blood products based on their beliefs. This situation presents a unique ethical and legal dilemma for healthcare providers when the neonate's family denies lifesaving treatment. We present a case study of a 24 weeks' gestation infant born to parents of JW beliefs, as well as a discussion of the pathophysiology and clinical manifestations of anemia.
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