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Updated: Jan 15, 2026
Listeria monocytogenes Infection of the Brain
Published on: October 2, 2018
Disseminated Listeria monocytogenes and human pegivirus-1 coinfection
Man Yuan1, Xiaoju Lv1, Yu Yuan2
1Center of Infectious Diseases, West China Hospital of Sichuan University, No. 37 Guoxue Alley Wuhou District, Chengdu, 610041, China.
Background:
Listeria monocytogenes is one of the major bacteria responsible for meningitis. Controversy exists regarding the neuropathological effect of human pegivirus-1 (HPgV-1). Whether HPgV-1 interacts with L. monocytogenes is unknown. Herein, we describe a multiple myeloma patient with disseminated L. monocytogenes and HPgV-1 coinfection.
Case Presentation:
The case of a 57-year-old patient with fever accompanied by headache, dizziness, nausea, vomiting of stomach contents, and urinary and faecal incontinence is presented. Through metagenomic next-generation sequencing and the detection of L. monocytogenes and HPgV-1 in cerebrospinal fluid, along with blood culture of L. monocytogenes and PCR of HPgV-1 in the blood, a diagnosis of HPgV-1 and L. monocytogenes meningitis, HPgV-1 viremia, and L. monocytogenes sepsis was made, enabling timely and proper treatment with meropenem. After treatment, the patient recovered and was discharged from the hospital.
Conclusions:
To our knowledge, this is the first reported case of disseminated L. monocytogenes and HPgV-1 coinfection. Determining whether HPgV-1 was responsible for meningitis will require further research, including histopathological analysis.
Insights
This case study reports the first instance of coinfection with Listeria monocytogenes and human pegivirus-1 (HPgV-1) in a multiple myeloma patient. The findings highlight a potential link between HPgV-1 and meningitis, warranting further investigation.
Area of Science:
- Infectious Diseases
- Neurology
- Virology
Background:
- Listeria monocytogenes is a primary cause of bacterial meningitis.
- The neuropathological role of human pegivirus-1 (HPgV-1) remains debated.
- The interaction between L. monocytogenes and HPgV-1 is not well understood.
Purpose of the Study:
- To describe a unique case of coinfection with L. monocytogenes and HPgV-1.
- To investigate the clinical presentation and diagnosis of this coinfection.
Main Methods:
- Metagenomic next-generation sequencing (mNGS) of cerebrospinal fluid (CSF).
- Detection of L. monocytogenes and HPgV-1 in CSF and blood.
- Blood culture for L. monocytogenes and PCR for HPgV-1.
Main Results:
- Diagnosis of HPgV-1 and L. monocytogenes meningitis, HPgV-1 viremia, and L. monocytogenes sepsis.
- Successful treatment with meropenem.
- Patient recovery and hospital discharge.
Conclusions:
- This is the first reported case of disseminated L. monocytogenes and HPgV-1 coinfection.
- Further research, including histopathological analysis, is needed to determine HPgV-1's role in meningitis.
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