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Published on: December 10, 2014
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Software and Hardware Complex for Assessment of Cerebral Autoregulation in Real Time
Vladimir Semenyutin1, Valeriy Antonov2, Galina Malykhina2
1Almazov National Medical Research Centre, Saint Petersburg 197341, Russia.
Sensors (Basel, Switzerland)
|October 16, 2025
Summary
This study introduces a new real-time system for measuring cerebral autoregulation (CA) using transcranial Dopplerography. The developed technology enables continuous monitoring of cerebral blood flow, crucial for timely CA-oriented therapy.
Area of Science:
- Neuroscience
- Biomedical Engineering
- Medical Technology
Background:
- Cerebral autoregulation (CA) assessment is vital for managing neurological conditions.
- Current CA measurements are retrospective, limiting real-time therapeutic interventions.
- Real-time CA monitoring is increasingly important, especially in intensive care settings.
Purpose of the Study:
- To develop and validate a hardware-software complex for real-time CA assessment.
- To enable continuous, non-invasive monitoring of cerebral blood flow regulation.
- To facilitate timely CA-oriented therapies through immediate data feedback.
Main Methods:
- Utilized transcranial Dopplerography for non-invasive cerebral blood flow velocity (BFV) measurement.
- Employed wavelet analysis to measure phase shift (PS) between BFV oscillations and systemic arterial pressure (BP) in the Mayer wave range.
- Developed a hardware-software complex for continuous, real-time signal analysis.
Main Results:
- Demonstrated the feasibility of continuous, real-time PS monitoring.
- Validated the system's capability to assess CA in real time.
- Confirmed the system's effectiveness in a study involving healthy volunteers and patients with neurovascular pathologies.
Conclusions:
- The developed hardware-software complex enables real-time monitoring of cerebral autoregulation.
- This technology offers a promising tool for studying cerebral blood flow regulation mechanisms.
- Real-time CA assessment can significantly improve therapeutic strategies in neurocritical care.
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