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Point-of-Care Testing and Biomarkers in Biliary Diseases: Current Evidence and Future Directions
Jang Han Jung1, Kyong Joo Lee1, Se Woo Park1
1Division of Gastroenterology, Department of Internal Medicine, Hallym University Dongtan Sacred Heart Hospital, Hallym University College of Medicine, Hwaseong 18450, Republic of Korea.
Point-of-care (POC) diagnostics and novel biomarkers offer improved early detection and management for biliary tract diseases. This review explores their utility and limitations, aiming to enhance patient outcomes through better clinical integration.
Area of Science:
- Gastroenterology and Hepatology
- Diagnostic Technologies
- Biomarker Discovery
Background:
- Biliary tract diseases pose diagnostic and management challenges.
- Current methods lack sensitivity and specificity for early detection and personalized treatment.
- Advancements in point-of-care (POC) diagnostics and biomarkers are transforming the field.
Purpose of the Study:
- To review the clinical utility and limitations of current POC tests and biomarkers for biliary tract diseases.
- To examine applications in acute management, chronic monitoring, and cancer detection.
- To identify gaps and propose strategies for integrating new tools into clinical workflows.
Main Methods:
- Comprehensive literature review of POC diagnostic technologies.
- Analysis of established biomarkers (e.g., CA19-9, CEA) and emerging molecular indicators (e.g., miRNA, ctDNA).
- Evaluation of diagnostic performance and clinical applicability.
Main Results:
- POC tests and novel biomarkers show promise for improved sensitivity and specificity.
- Established markers have limitations, while emerging markers require further validation.
- Applications span diagnosis, monitoring, and risk stratification.
Conclusions:
- POC diagnostics and novel biomarkers are crucial for advancing biliary tract disease management.
- Integration into clinical practice requires addressing current limitations and validating new tools.
- Enhanced diagnostic strategies can significantly improve patient outcomes.
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