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Respiratory System Compliance Predicts Outcome After Lung Transplantation-A Retrospective Single Center Study
Cecilia Veraar1, Stefan Schwarz2, Peter Wohlrab1
1Division of Cardiac Thoracic Vascular Anesthesia and Intensive Care Medicine, Department of Anesthesiology, Intensive Care Medicine and Pain Medicine, Medical University of Vienna, 1090 Vienna, Austria.
Journal of Clinical Medicine
|October 16, 2025
Summary
Respiratory system compliance (CRS) predicts mortality after lung transplantation (LUTX). Lower CRS is linked to increased 1-year mortality, while both CRS and mechanical power (MP) predict 30-day survival.
Area of Science:
- Cardiology
- Pulmonology
- Critical Care Medicine
Background:
- Predicting outcomes in lung transplantation (LUTX) for end-stage pulmonary disease is complex.
- Assessing prognostic value of respiratory system compliance (CRS) and mechanical power of ventilation (MP) post-surgery is crucial.
Purpose of the Study:
- To evaluate the prognostic significance of CRS and MP for mortality in LUTX patients.
- To identify key predictors for short-term (30-day) and long-term (1-year) survival.
Main Methods:
- Single-center retrospective study of 755 LUTX patients (2014-2023).
- Analysis of CRS and MP at end of surgery.
- Univariate, multivariate analyses, and ROC curve construction.
Main Results:
- 1-year mortality was 12.2%; 1.9% died within 30 days.
- Lower CRS (< 25.1 mL/cmH2O) independently predicted increased 1-year mortality.
- Both CRS and MP predicted 30-day survival (AUC 0.735-0.758).
Conclusions:
- Postoperative CRS is a significant independent predictor of short- and long-term outcomes in LUTX patients.
- Findings apply to patients with and without extracorporeal membrane oxygenation (ECMO) prolongation.
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