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Efficacy of a Computerized Therapeutic Decision-Making Algorithm in a Fracture Liaison Service Targeting Hip Fracture
Rachel Chava Rosenblum1,2, Arthur Kogan3, Dana Herzberg1,2
1Endocrinology Unit, Wolfson Medical Center, Holon 58100, Israel.
Journal of Clinical Medicine
|October 16, 2025
Summary
A nurse practitioner-led fracture liaison service (FLS) using a computer algorithm effectively recommends osteoporosis treatments for hip fracture patients, showing practicality with minimal physician input.
Area of Science:
- Gerontology
- Orthopedics
- Pharmacology
Background:
- Hip fractures represent a significant health burden in elderly populations.
- Effective management of osteoporosis is crucial to prevent subsequent fractures.
Purpose of the Study:
- To evaluate the efficacy of a nurse practitioner-managed, computer algorithm-supported fracture liaison service (FLS) for hip fracture patients.
- To assess the practicality and feasibility of an algorithm-based FLS model in providing treatment recommendations.
Main Methods:
- Retrospective study of 208 hip fracture patients.
- Utilized a decision-making algorithm for treatment recommendations, primarily zoledronic acid.
- Algorithm excluded patients younger than 65, with eGFR <35, or on prior osteoporosis therapy, referring them for endocrinology consultation.
- Administered Vitamin D loading doses for deficiency/insufficiency.
Main Results:
- Nurse practitioner evaluation occurred in 96.2% of patients.
- The algorithm provided recommendations in 70% of evaluated cases.
- Endocrinology consultation was required for 30% of patients.
- Vitamin D loading doses were administered in 89.9% of deficiency and 71.0% of insufficiency cases.
Conclusions:
- The algorithm-based FLS model is practical and feasible for generating osteoporosis treatment recommendations.
- This approach allows for effective management with minimal physician intervention.
- The FLS model streamlines care for hip fracture patients, improving osteoporosis management.

