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Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation
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Functional Capacity Evaluation and Rehabilitation Strategies in Cardiac Amyloidosis: A Comprehensive Review

Anthoula Plevritaki1, Konstantinos Volaklis2, Eleni Nakou3

  • 1School of Medicine, University of Crete, 71500 Giofirakia, Greece.

Journal of Clinical Medicine
|October 16, 2025
PubMed

Insights

Cardiac amyloidosis (CA) impairs heart function. Precise physiological assessments and rehabilitation are key to improving exercise tolerance, quality of life, and outcomes for CA patients.

Area of Science:

  • Cardiology
  • Cardiovascular Physiology
  • Amyloidosis Research

Background:

  • Cardiac amyloidosis (CA) is a growing cause of restrictive cardiomyopathy.
  • Amyloid deposition in the heart leads to severe functional decline and poor prognosis.

Purpose of the Study:

  • To provide a comprehensive overview of CA pathophysiology.
  • To emphasize mechanisms of functional limitation and the role of physiological assessment.
  • To highlight the importance of rehabilitation in managing CA.

Main Methods:

  • Review of pathophysiology of cardiac amyloidosis.
  • Focus on objective physiological assessment tools (e.g., exercise testing, frailty evaluation).
  • Analysis of evidence for multidisciplinary rehabilitation in CA patients.

Main Results:

  • Precise physiological assessments are vital for prognosis and patient care tailoring.
  • Disease-modifying therapies improve survival, making functional status a key target.
  • Structured exercise training shows potential to enhance exercise tolerance, strength, and quality of life.

Conclusions:

  • A patient-centered approach integrating clinical, physiological, and rehabilitative insights is crucial.
  • Preserving functional capacity is a vital goal for improving outcomes in cardiac amyloidosis.
  • Further research is needed to optimize rehabilitation protocols for CA.

Keywords:
6-min walk testcardiac amyloidosiscardiopulmonary exercise testingfrailtyfunctional capacityquality of liferehabilitationtransthyretin amyloidosis

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