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Updated: Jun 19, 2026
Engineering 3D Cellularized Collagen Gels for Vascular Tissue Regeneration
Published on: June 16, 2015
Cardiovascular Ischemia: Advancement and Potential Use of Collagen-Based Therapeutic Strategies
Ayodeji A Olabiyi1, Lisandra E de Castro Braz1
1Department of Physiology, Brody School of Medicine, East Carolina University, Greenville, NC 27858, USA.
Insights
Collagen treatment shows promise for treating myocardial infarction (MI) by aiding heart repair and regeneration. Further research is needed to fully understand its potential in cardiac recovery after ischemia.
Area of Science:
- Cardiovascular Biology
- Biomaterials Science
- Regenerative Medicine
Background:
- Myocardial infarction (MI) leads to heart muscle cell death and significant mortality.
- Post-MI maladaptive remodeling affects cardiac function in about 40% of patients.
- Current treatments aim to mitigate damage and support healing processes.
Purpose of the Study:
- To review existing studies on collagen treatment for myocardial ischemia.
- To evaluate the therapeutic potential of collagen and collagen-based biomaterials.
- To identify gaps in current research for future investigations.
Main Methods:
- Systematic review of literature on collagen treatment in myocardial ischemia.
- Analysis of studies focusing on collagen's role in cardiovascular health.
- Evaluation of collagen's impact on myocardial repair and regeneration.
Main Results:
- Collagen treatment supports blood pressure regulation, arterial health, and cholesterol management.
- Collagen-based biomaterials offer mechanical support and enhance stem cell retention.
- Collagen aids in delivering bioactive chemicals crucial for myocardial repair.
Conclusions:
- Collagen treatment presents a promising therapeutic strategy for myocardial ischemia.
- Collagen-based biomaterials are valuable for cardiac repair and regeneration.
- Further research is essential to elucidate the full potential and mechanisms of collagen in treating MI.
Abstract:
Cardiac ischemia causes a shortage of blood flow and oxygen to the heart muscle (i.e., myocardial infarction, MI), causing cell damage/death that initiates a cascade of healing processes. Every year, more than one million people in the United States die as a result of MI. After MI, approximately 40% of patients develop maladaptive myocardial remodeling that associates with decreasing cardiac function levels. Collagen treatment, particularly the use of collagen-based biomaterials as well as collagen supplementation, has shown promise in treating cardiac ischemia by supporting processes involved in blood pressure regulation, arterial health, and cholesterol management, mechanical support, increasing stem cell retention, and improving bioactive chemical delivery for myocardial repair and regeneration. In this review, we evaluate collagen treatment in myocardial ischemia based on existing studies and propose a missing link for future research.
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