Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Neuroplasticity01:01

Neuroplasticity

1.6K
Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.
1.6K
Cognitive Development During Adulthood01:30

Cognitive Development During Adulthood

770
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
770

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A 3D Microfluidic Blood-Brain Barrier Chip for Real-Time Assessment of Micro/Nanoplastics Permeability and Neuroinflammatory Injury.

ACS biomaterials science & engineering·2026
Same author

Appearance anxiety and college students' exercise participation: a chain mediation model of negative body image and exercise self-efficacy.

Frontiers in psychology·2026
Same author

<i>Astragaloside</i> IV in Combination with <i>Tanshinone</i> IIA Ameliorates Cardiac Fibrosis After Myocardial Infarction by Inhibiting CTR1/ATOX1/LOX Axis-Mediated Collagen Cross-Linking in Myofibroblasts.

Drug design, development and therapy·2026
Same author

The impact of physical exercise on medical expenditure among middle-aged and older adults: digital literacy as a moderating variable.

Frontiers in public health·2026
Same author

Theoretical study on the mechanism of 1,3,4-thiadiazole derivatives based on ESIPT and TICT as fluorescent probes for detecting Cu<sup>2</sup>.

Journal of molecular modeling·2026
Same author

SPINK4 affected M2 macrophage polarization to promote colorectal cancer malignant phenotype by PI3K/AKT pathway.

BMC cancer·2026

Related Experiment Video

Updated: Jan 15, 2026

Coherence between Brain Cortical Function and Neurocognitive Performance during Changed Gravity Conditions
12:29

Coherence between Brain Cortical Function and Neurocognitive Performance during Changed Gravity Conditions

Published on: May 23, 2011

20.0K

Spaceflight and Ground-Based Microgravity Simulation Impact on Cognition and Brain Plasticity.

Jiaqi Hao1, Jun Chang1, Yulin Deng1

  • 1School of Medical Technology, Beijing Institute of Technology, Beijing 100811, China.

International Journal of Molecular Sciences
|October 16, 2025
PubMed
Summary

Microgravity alters brain structure and function, leading to cognitive deficits. Future research should focus on neuroprotection for astronauts during long space missions.

Keywords:
cognitive functionmicrogravityneural plasticityneuroimagingspaceflight analog modelssynaptic plasticity

More Related Videos

Culturing Lymphocytes in Simulated Microgravity Using a Rotary Cell Culture System
09:28

Culturing Lymphocytes in Simulated Microgravity Using a Rotary Cell Culture System

Published on: August 25, 2022

3.5K
Assessment of Global Ocular Structure Following Spaceflight Using a Micro-Computed Tomography Micro-CT Imaging Method
09:11

Assessment of Global Ocular Structure Following Spaceflight Using a Micro-Computed Tomography Micro-CT Imaging Method

Published on: October 27, 2020

6.1K

Related Experiment Videos

Last Updated: Jan 15, 2026

Coherence between Brain Cortical Function and Neurocognitive Performance during Changed Gravity Conditions
12:29

Coherence between Brain Cortical Function and Neurocognitive Performance during Changed Gravity Conditions

Published on: May 23, 2011

20.0K
Culturing Lymphocytes in Simulated Microgravity Using a Rotary Cell Culture System
09:28

Culturing Lymphocytes in Simulated Microgravity Using a Rotary Cell Culture System

Published on: August 25, 2022

3.5K
Assessment of Global Ocular Structure Following Spaceflight Using a Micro-Computed Tomography Micro-CT Imaging Method
09:11

Assessment of Global Ocular Structure Following Spaceflight Using a Micro-Computed Tomography Micro-CT Imaging Method

Published on: October 27, 2020

6.1K

Area of Science:

  • Neuroscience
  • Space Medicine
  • Cognitive Science

Background:

  • Spaceflight-induced microgravity is associated with cognitive impairments.
  • Ground-based analogs confirm microgravity's disruptive effects on brain structure and neural plasticity.

Purpose of the Study:

  • To synthesize current evidence on the cognitive and neurobiological effects of microgravity.
  • To identify research gaps and potential neuroprotective strategies for space missions.

Main Methods:

  • Review of behavioral, structural, cellular, and molecular studies on microgravity's effects.
  • Analysis of neuroimaging, molecular, and omics data.

Main Results:

  • Microgravity disrupts brain morphology, functional connectivity, and cerebrospinal fluid dynamics.
  • Cellular changes include impaired synaptic plasticity, altered dendritic spines, and compromised neurotransmitter release.
  • Molecular pathways affected involve neuroendocrine signaling, neurotrophic factors, oxidative stress, and mitochondrial dysfunction.

Conclusions:

  • Microgravity significantly impacts cognitive function and brain biology.
  • Standardized, longitudinal human studies are needed to clarify mechanisms and translational relevance.
  • Developing neuroprotective strategies is crucial for astronaut health during extended space exploration.