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Evaluation and Modulation of Gut Microbiome Dysfunction in Chronically Critically Ill Patients: A Prospective Pilot
Ekaterina Chernevskaya1, Ekaterina Sorokina1, Petr Polyakov1
1Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Petrovka Str., Moscow 107031, Russia.
International Journal of Molecular Sciences
|October 16, 2025
Summary
A novel microbiota-oriented strategy shows promise for treating chronic critical illness (CCI) patients. This approach safely improved patient conditions and significantly reduced pneumonia incidence, offering a new therapeutic avenue.
Area of Science:
- Critical Care Medicine
- Microbiology
- Gastroenterology
Background:
- Gut microbiota disturbances are common in chronic critical illness (CCI) but challenging to manage.
- Assessing and modulating the gut microbiota in CCI patients requires effective strategies.
Purpose of the Study:
- To evaluate the safety and efficacy of a microbiota-oriented strategy for treating patients with CCI.
- To assess the impact of this strategy on patient biomarkers, neurological condition, inflammation, and infection rates.
Main Methods:
- A single-center prospective study included 43 CCI patients stratified by microbiota dysfunction severity.
- Three modulation regimens (metabiotics, enteral, anaerobic-safe antibiotics) were applied.
- Biomarker monitoring over 14 days and clinical outcomes over 28 days were assessed.
Main Results:
- The strategy was safe for mild to moderate microbiota dysfunction, reducing pharmacological load.
- Improvements were observed in neurological status, inflammation markers, and hematological/biochemical parameters.
- A significant reduction in the incidence of nosocomial pneumonia was noted.
Conclusions:
- A microbiota-oriented strategy is safe and effective for managing CCI patients.
- This approach shows potential for preventing nosocomial pneumonia in this vulnerable population.
Keywords:
aromatic microbial metabolitesbiomarkerschronic critical illnessmetabioticsmicrobiomemicrobiotaMore Related Videos
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