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Many receptor binding ligands are hydrophilic; they do not cross the cell membrane but bind to cell-surface receptors. Thus, their message must be relayed by second messengers present in the cell cytoplasm. There are several second messenger pathways, each with its own way of relaying information. For example, the G protein-coupled receptors can activate both phosphoinositol and cyclic AMP (cAMP) second messenger pathways. The phosphoinositol pathway is active when the receptor induces...
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P2Y2 Receptor Signaling in Health and Disease.

Fatemeh Salarpour1,2, Jean Sévigny1,2

  • 1Département de Microbiologie-Infectiologie et D'immunologie, Centres PROTEO et ARThrite, Faculté de Médecine, Université Laval, Québec City, QC G1V 0A6, Canada.

International Journal of Molecular Sciences
|October 16, 2025
PubMed
Summary
This summary is machine-generated.

P2Y2 receptors, activated by extracellular nucleotides, are crucial in tissue repair and immune responses. They also play significant roles in diseases like Alzheimer's and dry eye, making them key therapeutic targets.

Keywords:
P2Y2 receptorbreast cancercalcium signalingcystic fibrosisdry eye diseaseextracellular nucleotidesinflammationneurodegenerative diseasesnucleotide receptorstissue repair

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Area of Science:

  • Molecular Biology
  • Cell Biology
  • Pharmacology

Background:

  • P2Y2 receptors are G protein-coupled receptors activated by extracellular nucleotides ATP and UTP.
  • They are expressed in various tissues and involved in inflammation, wound healing, and cell migration.
  • P2Y2 receptor signaling influences calcium mobilization, cytokine release, and cytoskeletal reorganization.

Purpose of the Study:

  • To explore the multifaceted roles of P2Y2 receptors in both physiological and pathological conditions.
  • To highlight the therapeutic potential of P2Y2 receptors in diverse diseases.

Main Methods:

  • Review of recent studies on P2Y2 receptor function.
  • Analysis of P2Y2 receptor involvement in various disease models.

Main Results:

  • P2Y2 receptors contribute to immune modulation and tissue repair in healthy states.
  • In diseases, they are implicated in Alzheimer's, dry eye, cystic fibrosis, inflammatory bowel disease, breast cancer, blood pressure regulation, and HIV-1 entry.
  • These receptors exhibit dual roles, promoting beneficial functions in health and contributing to pathology in disease.

Conclusions:

  • P2Y2 receptors have diverse functions in multiple tissues and signaling pathways.
  • Their involvement in various diseases highlights their clinical significance.
  • P2Y2 receptors represent promising therapeutic targets for a wide range of conditions.